Publicación:
Las plantas como fuente de compuestos fotoprotectores frente al daño en el ADN producido por la radiación ultravioleta

dc.contributor.authorFuentes Lorenzo, Jorge L.
dc.contributor.corporatenameAcademia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.date.accessioned2021-12-09T23:26:51Z
dc.date.available2021-12-09T23:26:51Z
dc.date.issued2019-09-25
dc.description.abstractLa fotoprotección es una estrategia preventiva y terapéutica frente al cáncer y el envejecimiento de la piel. En el presente trabajo se revisan los efectos biológicos adversos de la radiación ultravioleta, los conceptos básicos relevantes de la fotoprotección y los métodos para llevar a cabo su medición. Asimismo, se resumen los resultados obtenidos de la caracterización radiobiológica y genética del modelo experimental (SOS Chromotest) usado para la bioprospección de extractos y moléculas de origen vegetal con potencial en fotoprotección. Además, se presentan datos sobre la eficacia fotoprotectora y las estimaciones del efecto antigenotóxico de aceites esenciales y extractos obtenidos de especies de plantas, así como de los compuestos mayoritarios de los aceites y extractos promisorios analizados en este estudio. Por último, se postulan posibles mecanismos de acción de algunas moléculas relevantes. Los resultados se presentan y discuten destacando su potencial uso para el desarrollo de bloqueadores solares multifuncionales.spa
dc.description.abstractPhotoprotection is a preventive and therapeutic strategy against skin cancer and photoaging. In the present work, we review the adverse biological effects of the ultraviolet radiation, the basic concepts with relevance in photoprotection, and the methods to carry out its measurement. Likewise, we summarized the main results obtained from the radiobiological and genetic characterization of the SOS Chromotest model, which we used for bioprospecting photoprotective activity of plant extracts and molecules. Besides, we showed photoprotective efficacy and/or antigenotoxicity estimates of plant essential oils and extracts, as well as of the major compounds of promissory oils and extracts analyzed in our study. Finally, action mechanisms of the relevant molecules are postulated. These results are presented and discussed considering their potential use to formulate multifunctional sunscreen.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.18257/raccefyn.841
dc.identifier.urihttps://repositorio.accefyn.org.co/handle/001/1162
dc.language.isospaspa
dc.publisherAcademia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.publisher.placeBogotá, Colombiaspa
dc.relation.citationendpage562spa
dc.relation.citationissue168spa
dc.relation.citationstartpage550spa
dc.relation.citationvolume43spa
dc.relation.ispartofjournalRevista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 Internationalspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourceRevista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.subject.proposalRadiación ultravioletaspa
dc.subject.proposalUltraviolet radiationeng
dc.subject.proposalFotoprotecciónspa
dc.subject.proposalPhotoprotectioneng
dc.subject.proposalAntigenotoxicidadspa
dc.subject.proposalAntigenotoxicityeng
dc.subject.proposalMetabolitos secundarios de plantasspa
dc.subject.proposalPlant secondary metaboliteseng
dc.titleLas plantas como fuente de compuestos fotoprotectores frente al daño en el ADN producido por la radiación ultravioletaspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentDataPaperspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceEstudiantes, Profesores, Comunidad científica colombianaspa
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