Publicación:
Los diversos efectos de las helmintiasis sobre la inflamación alérgica

dc.contributor.authorCaraballo, Luis
dc.contributor.corporatenameAcademia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.date.accessioned2021-11-15T13:18:06Z
dc.date.available2021-11-15T13:18:06Z
dc.date.issued2016-07-03
dc.description.abstractLas helmintiasis y las alergias son muy frecuentes en países del trópico, donde establecen múltiples interacciones. Los mecanismos de defensa contra estos parásitos son bastante parecidos a la respuesta inmunológica de tipo alérgico, principalmente porque ambos procesos tienen una importante participación de los anticuerpos tipo inmunoglobulina E (IgE). Pero también hay diferencias importantes, siendo una de ellas el grado de inmunomodulación, el cual es débil en la respuesta alérgica y fuerte en la antihelmíntica. Este tema tiene repercusiones en medicina porque algunas helmintiasis como la ascariasis (producida por Ascaris lumbricoides), son capaces de modificar el curso de las enfermedades alérgicas, en ocasiones disminuyendo su intensidad, por lo cual se ha propuesto que una de las razones del incremento de las alergias en el mundo es la disminución progresiva de las infecciones por helmintos. En esta revisión analizaremos varios de los efectos de las helmintiasis sobre la respuesta inmunológica alérgica y especularemos sobre su influencia en las tendencias internacionales de incremento de los problemas inflamatorios de origen inmunológico.spa
dc.description.abstractHelminth infections and allergies are very common in tropical countries, where they are linked by multiple interactions. Defense mechanisms against helminths are quite similar to the allergic immune response, mainly because both processes have a significant participation of antibodies such as immunoglobulin E (IgE). But there are also important differences, one being the degree of immunomodulation, which is weak in the allergic response and strong in anthelmintic immunity. This issue has implications in medicine because some helminth infections such as ascariasis (caused by Ascaris lumbricoides), are able to modify the course of allergic diseases, sometimes reducing their intensity and sometimes intensifying allergic symptoms. In this review we discuss some of the influence of helminthiases on the allergic immune response and speculate about its impact on the current international prevalence trends of inflammatory disorders.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.18257/raccefyn.355
dc.identifier.urihttps://repositorio.accefyn.org.co/handle/001/921
dc.language.isospaspa
dc.publisherAcademia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.publisher.placeBogotá, Colombiaspa
dc.relation.citationendpage208spa
dc.relation.citationissue155spa
dc.relation.citationstartpage200spa
dc.relation.citationvolume40spa
dc.relation.ispartofjournalRevista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 Internationalspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourceRevista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.subject.proposalHelmintiasisspa
dc.subject.proposalHelminthiaseseng
dc.subject.proposalImmunomodulaciónspa
dc.subject.proposalImmunomodulationeng
dc.subject.proposalIgEspa
dc.subject.proposalIgEeng
dc.subject.proposalAlergiaspa
dc.subject.proposalAllergyeng
dc.subject.proposalEpidemiologíaspa
dc.subject.proposalEpidemiologyeng
dc.subject.proposalRespuesta alérgicaspa
dc.subject.proposalAllergic responseeng
dc.titleLos diversos efectos de las helmintiasis sobre la inflamación alérgicaspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentDataPaperspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dcterms.audienceEstudiantes, Profesores, Comunidad científica colombianaspa
dcterms.referencesAcevedo, N. & Caraballo, L. (2011). IgE cross-reactivity between Ascaris lumbricoides and mite allergens: possible influences on allergic sensitization and asthma. Parasite Immunol33: 309-21.spa
dcterms.referencesAcevedo, N., Erler, A., Briza, P., Puccio, F., Ferreira, F. & Caraballo, L. (2011). Allergenicity of Ascaris lumbricoides tropomyosin and IgE sensitization among asthmatic patients in a tropical environment. Int Arch Allergy Immunol154: 195-206spa
dcterms.referencesAcevedo, N., Mercado, D., Vergara, C., Sánchez, J., Kennedy, M. W., Jiménez, S., Fernández, A. M., Gutiérrez, M., Puerta, L. & Caraballo, L. (2009a). Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes. Clin Exp Immunol157: 282-90spa
dcterms.referencesAcevedo, N., Mohr, J., Zakzuk, J., Samonig, M., Briza, P., Erler, A., Pomes, A., Huber, C. G., Ferreira, F. & Caraballo, L. (2013). Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides. PLoS One8: e78353spa
dcterms.referencesAcevedo, N., Sanchez, J., Erler, A., Mercado, D., Briza, P., Kennedy, M., Fernandez, A., Gutierrez, M., Chua, K. Y., Cheong, N., Jimenez, S., Puerta, L. & Caraballo, L. (2009b). IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1. Allergy64: 1635-43spa
dcterms.referencesAcevedo, N., Sanchez, J., Zakzuk, J., Bornacelly, A., Quiroz, C., Alvarez, A., Puello, M., Mendoza, K., Martinez, D., Mercado, D., Jimenez, S. & Caraballo, L. (2012). Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study. BMC Pulm Med12: 13.spa
dcterms.referencesAgudelo-Lopez, S., Gomez-Rodriguez, L., Coronado, X., Orozco, A., Valencia-Gutierrez, C. A., Restrepo-Betancur, L. F., Galvis-Gomez, L. A. & Botero-Palacio, L. E. (2008). [Prevalence of intestinal parasitism and associated factors in a village on the Colombian Atlantic Coast]. Rev Salud Publica (Bogota) 10: 633-42spa
dcterms.referencesAhumada, V., Garcia, E., Dennis, R., Rojas, M. X., Rondon, M. A., Perez, A., Penaranda, A., Barragan, A. M., Jimenez, S., Kennedy, M. W. & Caraballo, L. (2015). IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. Clin Exp Allergy45: 1189-1200spa
dcterms.referencesAntunes, M. F., Titz, T. O., Batista, I. F., Marques-Porto, R., Oliveira, C. F., Alves de Araujo, C. A. & Macedo-Soares, M. F. (2015). Immunosuppressive PAS-1 is an excretory/secretory protein released by larval and adult worms of the ascarid nematode Ascaris suum. J Helminthol89: 367-74spa
dcterms.referencesBuendía, E. (2015). The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity. WAO Journal8: 8spa
dcterms.referencesCaraballo, L. (2013). Ascaris and Allergy. In Ascaris: the neglected parasite (ed. C. V. Holland), pp. 21-50. Elsevierspa
dcterms.referencesCaraballo, L. & Acevedo, N. (2011). New allergens of relevance in tropical regions: the impact of Ascaris lumbricoides infections. WAO Journal4: 77-84spa
dcterms.referencesCaraballo, L. & Ahumada, V. (2016). Reply to ‘Comments on IgE responses to Ascaris and mite tropomyosins are risk factors for asthma’. Clin Exp Allergy46: 181spa
dcterms.referencesCaraballo L, A. N., Buendía E. (2015). Human Ascariasis Increases the Allergic Response and Allergic Symptoms. Curr Trop Med Rep2: 224-232spa
dcterms.referencesCarmona Fonseca Jaime , U. R., Correa Botero Adriana María (2009). Parasitosis intestinal en niños de zonas palúdicas de Antioquia (Colombia). IATREIA22: 28-46spa
dcterms.referencesCarvalho Kdos, A., de Melo-Neto, O. P., Magalhaes, F. B., Ponte, J. C., Felipe, F. A., dos Santos, M. C., dos Santos Lima, G., Cruz, A. A., Pinheiro, C. S., Pontes-de-Carvalho, L. C. & Alcantara-Neves, N. M. (2013). Blomia tropicalis Blo t 5 and Blo t 21 recombinant allergens might confer higher specificity to serodiagnostic assays than whole mite extract. BMC Immunol14: 11spa
dcterms.referencesCooper, P. J., Chico, M. E., Amorim, L. D., Sandoval, C., Vaca, M., Strina, A., Campos, A. C., Rodrigues, L. C., Barreto, M. L. & Strachan, D. P. (2016). Effects of maternal geohelminth infections on allergy in early childhood. J Allergy Clin Immunol137: 899-906 e2spa
dcterms.referencesCooper, P. J., Chico, M. E., Rodrigues, L. C., Strachan, D. P., Anderson, H. R., Rodriguez, E. A., Gaus, D. P. & Griffin, G. E. (2004). Risk factors for atopy among school children in a rural area of Latin America. Clin Exp Allergy34: 845-52spa
dcterms.referencesCoronado S, e. a. (2016). A recombinant cystatin from Ascaris lumbricoides has immunomodulatory effects. Journal of Allergy and Clinical Immunology137: AB228spa
dcterms.referencesDennis, R. J., Caraballo, L., Garcia, E., Rojas, M. X., Rondon, M. A., Perez, A., Aristizabal, G., Penaranda, A., Barragan, A. M., Ahumada, V. & Jimenez, S. (2012). Prevalence of asthma and other allergic conditions in Colombia 2009-2010: a cross-sectional study. BMC Pulm Med12: 17spa
dcterms.referencesElliott, D. E. & Weinstock, J. V. (2012). Where are we on worms? Curr Opin Gastroenterol28: 551-6spa
dcterms.referencesEndara, P., Vaca, M., Chico, M. E., Erazo, S., Oviedo, G., Quinzo, I., Rodriguez, A., Lovato, R., Moncayo, A. L., Barreto, M. L., Rodrigues, L. C. & Cooper, P. J. (2010). Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity. Clin Exp Allergy40:1669-77spa
dcterms.referencesEndara, P., Vaca, M., Platts-Mills, T. A., Workman, L., Chico, M. E., Barreto, M. L., Rodrigues, L. C. & Cooper, P. J. (2015). Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis. Clin Exp Allergy45: 438-47spa
dcterms.referencesFeillet, H. & Bach, J. F. (2004). Increased incidence of inflammatory bowel disease: the price of the decline of infectious burden? Curr Opin Gastroenterol20: 560-4spa
dcterms.referencesFigueiredo, C. A., Barreto, M. L., Rodrigues, L. C., Cooper, P. J., Silva, N. B., Amorim, L. D. & Alcantara-Neves, N. M. (2010). Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network. Infect Immun78: 3160-7spa
dcterms.referencesGerbe, F., Sidot, E., Smyth, D. J., Ohmoto, M., Matsumoto, I., Dardalhon, V., Cesses, P., Garnier, L., Pouzolles, M., Brulin, B., Bruschi, M., Harcus, Y., Zimmermann, V. S., Taylor, N., Maizels, R. M. & Jay, P. (2016). Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature529: 226-30spa
dcterms.referencesHaahtela, T., Holgate, S., Pawankar, R., Akdis, C. A., Benjaponpitak, S., Caraballo, L., Demain, J., Portnoy, J., von Hertzen, L., Change, W. A. O. S. C. o. C. & Biodiversity (2013). The biodiversity hypothesis and allergic disease: world allergy organization position statement. World Allergy Organ J6: 3.spa
dcterms.referencesHagan, P., Blumenthal, U. J., Dunn, D., Simpson, A. J. & Wilkins, H. A. (1991). Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature349:243-5spa
dcterms.referencesHagel, I., Cabrera, M., Puccio, F., Santaella, C., Buvat, E., Infante, B., Zabala, M., Cordero, R. & Di Prisco, M. C. (2011). Co-infection with Ascaris lumbricoides modulates protective immune responses against Giardia duodenalis in school Venezuelan rural children. Acta Trop117: 189-95spa
dcterms.referencesHarnett, W. (2014). Secretory products of helminth parasites as immunomodulators. Mol Biochem Parasitol195: 130-6spa
dcterms.referencesHawlader, M. D., Ma, E., Noguchi, E., Itoh, M., Arifeen, S. E., Persson, L. A., Moore, S. E., Raqib, R. & Wagatsuma, Y. (2014). Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children. Trop Med Health42: 77-85spa
dcterms.referencesHunninghake, G. M., Soto-Quiros, M. E., Avila, L., Ly, N. P., Liang, C., Sylvia, J. S., Klanderman, B. J., Silverman, E. K. & Celedon, J. C. (2007). Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol119: 654-61spa
dcterms.referencesHussaarts, L., van der Vlugt, L. E., Yazdanbakhsh, M. & Smits, H. H. (2011). Regulatory B-cell induction by helminths: implications for allergic disease. J Allergy Clin Immunol128: 733-9.spa
dcterms.referencesJex, A. R., Liu, S., Li, B., Young, N. D., Hall, R. S., Li, Y., Yang, L., Zeng, N., Xu, X., Xiong, Z., Chen, F., Wu, X., Zhang, G., Fang, X., Kang, Y., Anderson, G. A., Harris, T. W., Campbell, B. E., Vlaminck, J., Wang, T., Cantacessi, C., Schwarz, E. M., Ranganathan, S., Geldhof, P., Nejsum, P., Sternberg, P. W., Yang, H., Wang, J., Wang, J. & Gasser, R. B. (2011). Ascaris suum draft genome. Nature479: 529-33spa
dcterms.referencesJoubert, J. R., de Klerk, H. C. & Malan, C. (1979). Ascaris lumbricoides and allergic asthma: A new perspective. S Afr Med J56: 599-602spa
dcterms.referencesKolkhir, P., Balakirski, G., Merk, H. F., Olisova, O. & Maurer, M. (2016). Chronic spontaneous urticaria and internal parasites - a systematic review. Allergy71: 308-22.spa
dcterms.referencesLarson, D., Cooper, P. J., Hubner, M. P., Reyes, J., Vaca, M., Chico, M., Kong, H. H. & Mitre, E. (2012). Helminth infection is associated with decreased basophil responsiveness in human beings. J Allergy Clin Immunol130: 270-2spa
dcterms.referencesLondono, A. L., Mejia, S. & Gomez-Marin, J. E. (2009). [Prevalence and risk factors associated with intestinal parasitism in preschool children from the urban area of Calarca, Colombia]. Rev Salud Publica (Bogota) 11: 72-81spa
dcterms.referencesLynch, N. R., Hagel, I. A., Palenque, M. E., Di Prisco, M. C., Escudero, J. E., Corao, L. A., Sandia, J. A., Ferreira, L. J., Botto, C., Perez, M. & Le Souef, P. N. (1998). Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol101: 217-21spa
dcterms.referencesLynch, N. R., Palenque, M., Hagel, I. & DiPrisco, M. C. (1997). Clinical improvement of asthma after anthelminthic treatment in a tropical situation. Am J Respir Crit Care Med156: 50-4.spa
dcterms.referencesMaizels, R. M., McSorley, H. J. & Smyth, D. J. (2014). Helminths in the hygiene hypothesis: sooner or later? Clin Exp Immunol177: 38-46.spa
dcterms.referencesMallol, J., Crane, J., von Mutius, E., Odhiambo, J., Keil, U., Stewart, A. & Group, I. P. T. S. (2013). The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: a global synthesis. Allergol Immunopathol (Madr)41: 73-85.spa
dcterms.referencesMcSharry, C., Xia, Y., Holland, C. V. & Kennedy, M. W. (1999). Natural immunity to Ascaris lumbricoides associated with immunoglobulin E antibody to ABA-1 allergen and inflammation indicators in children. Infect Immun67: 484-9.spa
dcterms.referencesMetenou, S., Dembele, B., Konate, S., Dolo, H., Coulibaly, S. Y., Coulibaly, Y. I., Diallo, A. A., Soumaoro, L., Coulibaly, M. E., Sanogo, D., Doumbia, S. S., Traore, S. F., Mahanty, S., Klion, A. & Nutman, T. B. (2010). At homeostasis filarial infections have expanded adaptive T regulatory but not classical Th2 cells. J Immunol184:5375-82spa
dcterms.referencesMkhize-Kwitshana, Z. L. & Mabaso, M. L. (2014). The neglected triple disease burden and interaction of helminths, HIV and tuberculosis: an opportunity for integrated action in South Africa. S Afr Med J104: 258, 259spa
dcterms.referencesOsborne, L. C., Monticelli, L. A., Nice, T. J., Sutherland, T. E., Siracusa, M. C., Hepworth, M. R., Tomov, V. T., Kobuley, D., Tran, S. V., Bittinger, K., Bailey, A. G., Laughlin, A. L., Boucher, J. L., Wherry, E. J., Bushman, F. D., Allen, J. E., Virgin, H. W. & Artis, D. (2014). Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation. Science345: 578-82spa
dcterms.referencesPearce, N., Ait-Khaled, N., Beasley, R., Mallol, J., Keil, U., Mitchell, E. & Robertson, C. (2007). Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax62: 758-66spa
dcterms.referencesPitrez, P. M., Gualdi, L. P., Barbosa, G. L., Sudbrack, S., Ponzi, D., Cao, R. G., Silva, A. C., Machado, D. C., Jones, M. H., Stein, R. T. & Graeff-Teixeira, C. (2015). Effect of different helminth extracts on the development of asthma in mice: The influence of early-life exposure and the role of IL-10 response. Exp Parasitol156: 95-103spa
dcterms.referencesPlatts-Mills, T. A. & Cooper, P. J. (2010). Differences in asthma between rural and urban communities in South Africa and other developing countries. J Allergy Clin Immunol125:106-7spa
dcterms.referencesPullan, R. L., Smith, J. L., Jasrasaria, R. & Brooker, S. J. (2014). Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. Parasit Vectors7: 37.spa
dcterms.referencesReese, T. A., Wakeman, B. S., Choi, H. S., Hufford, M. M., Huang, S. C., Zhang, X., Buck, M. D., Jezewski, A., Kambal, A., Liu, C. Y., Goel, G., Murray, P. J., Xavier, R. J., Kaplan, M. H., Renne, R., Speck, S. H., Artyomov, M. N., Pearce, E. J. & Virgin, H. W. (2014). Helminth infection reactivates latent gamma-herpesvirus via cytokine competition at a viral promoter. Science345: 573-7spa
dcterms.referencesRodrigues, L. C., Newcombe, P. J., Cunha, S. S., Alcantara-Neves, N. M., Genser, B., Cruz, A. A., Simoes, S. M., Fiaccone, R., Amorim, L., Cooper, P. J., Barreto, M. L., Social Change, A. & Allergy in Latin, A. (2008). Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood. Clin Exp Allergy38: 1769-77spa
dcterms.referencesRodriguez, A., Vaca, M., Oviedo, G., Erazo, S., Chico, M. E., Teles, C., Barreto, M. L., Rodrigues, L. C. & Cooper, P. J. (2011). Urbanisation is associated with prevalence of childhood asthma in diverse, small rural communities in Ecuador. Thorax66: 1043-50.spa
dcterms.referencesSalgame, P., Yap, G. S. & Gause, W. C. (2013). Effect of helminth-induced immunity on infections with microbial pathogens. Nat Immunol14: 1118-26.spa
dcterms.referencesSchierack, P., Lucius, R., Sonnenburg, B., Schilling, K. & Hartmann, S. (2003). Parasite-specific immunomodulatory functions of filarial cystatin. Infect Immun71: 2422-9spa
dcterms.referencesSmits, H. H. & Akdis, C. A. (2014). In utero priming by worms protects against respiratory allergies. J Allergy Clin Immunol134: 1280-1.spa
dcterms.referencesSpillmann, R. K. (1975). Pulmonary ascariasis in tropical communities. Am J Trop Med Hyg24: 791-800spa
dcterms.referencesStein, M., Greenberg, Z., Boaz, M., Handzel, Z. T., Meshesha, M. K. & Bentwich, Z. (2016). The Role of Helminth Infection and Environment in the Development of Allergy: A Prospective Study of Newly-Arrived Ethiopian Immigrants in Israel. PLoS Negl Trop Dis10: e0004208.spa
dcterms.referencesStraubinger, K., Paul, S., Prazeres da Costa, O., Ritter, M., Buch, T., Busch, D. H., Layland, L. E. & Prazeres da Costa, C. U. (2014). Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation. J Allergy Clin Immunol134; 1271-1279 e10.spa
dcterms.referencesTakeuchi, H., Khan, A. F., Hasan, M. I., Hawlader, M. D., Yunus, M., Zaman, K., Chowdhury, H. R., Takanashi, S., Wagatsuma, Y. & Iwata, T. (2016). Comment on IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. Clin Exp Allergy46; 178-80.spa
dcterms.referencesTakeuchi, H., Khan, A. F., Yunus, M., Hasan, M. I., Hawlader, M. D., Takanashi, S., Kano, H., Zaman, K., Chowdhury, H. R., Wagatsuma, Y., Nakahara, S. & Iwata, T. (2015). Anti-Ascaris immunoglobulin E associated with bronchial hyper-reactivity in 9-year-old rural Bangladeshi children. Allergol Intspa
dcterms.referencesTakeuchi, H., Zaman, K., Takahashi, J., Yunus, M., Chowdhury, H. R., Arifeen, S. E., Baqui, A., Wakai, S. & Iwata, T. (2008). High titre of anti-Ascaris immunoglobulin E associated with bronchial asthma symptoms in 5-year-old rural Bangladeshi children. Clin Exp Allergy38: 276-82.spa
dcterms.referencesvan den Biggelaar, A. H., van Ree, R., Rodrigues, L. C., Lell, B., Deelder, A. M., Kremsner, P. G. & Yazdanbakhsh, M. (2000). Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet356: 1723-7.spa
dcterms.referencesZakzuk, J. (2016). Inmunorregulación inducida por helmintos: una actualización. . Iatreia29: 182-193.spa
dcterms.referencesZakzuk, J., Bornacelly, A., Mercado, D., Sánchez, J., Acevedo, N., Caraballo, L. (2014). The evolution of IgE sensitization to Ascaris allergenic components in early infancy. In Allergic diseases: from mechanisms to cure (ed. S. J. Galli, You-Young Kim), pp. 29-31. Pacini Editore: Italy.spa
dcterms.referencesZakzuk, J., Jimenez, S., Cheong, N., Puerta, L., Lee, B. W., Chua, K. Y. & Caraballo, L. (2009). Immunological characterization of a Blo t 12 isoallergen: identification of immunoglobulin E epitopes. Clin Exp Allergy39: 608-16spa
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