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Title: Serological comparison of the two morphological phases of paracoccidioides brasiliensis
Authors: Restrepo Moreno, Ángela
Issue Date: 1970
Publisher: American Society for Microbiology
Abstract: The antigenic relationship of six different strains of Paracoccidioides brasiliensis was investigated by the agar-gel immunodiffusion test. Soluble antigens prepared from the two morphological phases of the fungus were diffused against human sera obtained from eight patients with paracoccidioidomycosis (South American blastomycosis). The mycelial phase showed common antigenic determinants as revealed by the formation of identical precipitin bands. The yeast phase proved to be more complex. Most of the strains produced a common antigen, but reactions of partial identity and of nonidentity were recorded for two strains. Antigens common to both mycelial and yeast phases were observed in five strains. The remaining strains, however, contained different antigenic determinants. The results of the experiment suggest that P. brasiliensis in its yeast form is not an antigenically homogeneous organism.
La relación antigénica de seis cepas diferentes de Paracoccidioides brasiliensis se investigó mediante la prueba de inmunodifusión en gel de agar. Se difundieron antígenos solubles preparados a partir de las dos fases morfológicas del hongo contra sueros humanos obtenidos de ocho pacientes con paracoccidioidomicosis (blastomicosis sudamericana). La fase micelial mostró determinantes antigénicos comunes como lo revela la formación de bandas de precipitina idénticas. La fase de la levadura resultó ser más compleja. La mayoría de las cepas produjeron un antígeno común, pero se registraron reacciones de identidad parcial y de no identidad para dos cepas. Se observaron antígenos comunes a las fases de micelio y levadura en cinco cepas. Sin embargo, las cepas restantes contenían diferentes determinantes antigénicos. Los resultados del experimento sugieren que P. brasiliensis en su forma de levadura no es un organismo antigénicamente homogéneo.
ISSN: 0019-9567
Document url:
DOI: 10.1128/iai.2.3.268-273.1970
Appears in Collections:DHAC Paracoccidioidomicosis. Diagnóstico

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