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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Quiroga Puello, Jairo | - |
| dc.date.accessioned | 2021-12-09T23:25:33Z | - |
| dc.date.available | 2021-12-09T23:25:33Z | - |
| dc.date.issued | 2019-09-25 | - |
| dc.identifier.uri | https://repositorio.accefyn.org.co/handle/001/1160 | - |
| dc.description.abstract | Los compuestos heterocíclicos ocupan un lugar importante entre los grandes grupos o familias de compuestos que conforman la química orgánica, no solo por la diversidad estructural y las propiedades químicas que los hacen atractivos como auxiliares sintéticos, sino porque los núcleos heterocíclicos son constituyentes de productos naturales y juegan un papel clave en los procesos biológicos, lo que explica su aplicación como agentes terapéuticos. Además, muchos de los medicamentos para el tratamiento de diversas enfermedades poseen unidades estructurales heterocíclicas, lo que convierte a estos compuestos en objetivos de la química medicinal. En este estudio se presenta un resumen de la investigación del autor y su grupo sobre el tema de los aminopirazoles y su importancia en la síntesis de compuestos heterocíclicos de mayor complejidad. El diseño, la síntesis y el estudio estructural de los nuevos compuestos sintetizados que contienen el núcleo del pirazol se hicieron en el Grupo de Investigación de Compuestos Heterocíclicos (GICH) del Departamento de Química de la Universidad del Valle, con la colaboración de instituciones nacionales e internacionales, con el objetivo de estudiar la posible actividad antitumoral, antifúngica y antibacteriana de algunos de los nuevos compuestos sintetizados. | spa |
| dc.description.abstract | Heterocyclic compounds have an important place among the large groups or families of compounds that make up organic chemistry. This is not only due to its structural diversity and chemical properties, which makes them attractive as synthetic auxiliaries, but also because their heterocyclic nuclei are constituents of natural products and play a key role in biological processes. Their application as therapeutic agents for the treatment of various diseases also turns their structural units in targets of medicinal chemistry. This study is a summary of the research conducted by the author and his group on the subject of aminopyrazoles and their importance in the synthesis of heterocyclic compounds of greater complexity. The design, synthesis, and study of new compounds containing the pyrazole nucleus have been carried out in the Heterocyclic Compounds Research Group (GICH) of the Chemistry Department at Valle University where together with other national and international institutions, we have studied the possible antitumor, antifungal, and antibacterial activity of some of the new compounds. | eng |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | spa | spa |
| dc.publisher | Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International | spa |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
| dc.source | Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
| dc.title | Los 5-aminopirazoles como bloque de construcción de compuestos heterocíclicos fusionados | spa |
| dc.type | Artículo de revista | spa |
| dcterms.audience | Estudiantes, Profesores, Comunidad científica colombiana | spa |
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| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.type.driver | info:eu-repo/semantics/article | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
| dc.rights.creativecommons | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | spa |
| dc.identifier.doi | https://doi.org/10.18257/raccefyn.762 | - |
| dc.subject.proposal | Hidracinas | spa |
| dc.subject.proposal | Hydrazines | eng |
| dc.subject.proposal | Nitrilos | spa |
| dc.subject.proposal | Nitriles | eng |
| dc.subject.proposal | Aminopirazol | spa |
| dc.subject.proposal | Aminopyrazole | eng |
| dc.subject.proposal | Bielectrófilos | spa |
| dc.subject.proposal | Bielectrophiles | eng |
| dc.subject.proposal | Compuestos con metileno activo | spa |
| dc.subject.proposal | Methylene active compounds | eng |
| dc.subject.proposal | Pirazolopiridina | spa |
| dc.subject.proposal | Pyrazolopyridine | eng |
| dc.subject.proposal | Pirazolopirimidina | spa |
| dc.subject.proposal | Pyrazolopyrimidine | eng |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
| dc.relation.ispartofjournal | Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
| dc.relation.citationvolume | 43 | spa |
| dc.relation.citationstartpage | 531 | spa |
| dc.relation.citationendpage | 538 | spa |
| dc.publisher.place | Bogotá, Colombia | spa |
| dc.contributor.corporatename | Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
| dc.relation.citationissue | 168 | spa |
| dc.type.content | DataPaper | spa |
| dc.type.redcol | http://purl.org/redcol/resource_type/ART | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
| Appears in Collections: | BA. Revista de la Academia Colombiana de Ciencias Exactas Físicas y Naturales | |
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