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dc.contributor.authorQuiroga Puello, Jairo-
dc.date.accessioned2021-12-09T23:25:33Z-
dc.date.available2021-12-09T23:25:33Z-
dc.date.issued2019-09-25-
dc.identifier.urihttps://repositorio.accefyn.org.co/handle/001/1160-
dc.description.abstractLos compuestos heterocíclicos ocupan un lugar importante entre los grandes grupos o familias de compuestos que conforman la química orgánica, no solo por la diversidad estructural y las propiedades químicas que los hacen atractivos como auxiliares sintéticos, sino porque los núcleos heterocíclicos son constituyentes de productos naturales y juegan un papel clave en los procesos biológicos, lo que explica su aplicación como agentes terapéuticos. Además, muchos de los medicamentos para el tratamiento de diversas enfermedades poseen unidades estructurales heterocíclicas, lo que convierte a estos compuestos en objetivos de la química medicinal. En este estudio se presenta un resumen de la investigación del autor y su grupo sobre el tema de los aminopirazoles y su importancia en la síntesis de compuestos heterocíclicos de mayor complejidad. El diseño, la síntesis y el estudio estructural de los nuevos compuestos sintetizados que contienen el núcleo del pirazol se hicieron en el Grupo de Investigación de Compuestos Heterocíclicos (GICH) del Departamento de Química de la Universidad del Valle, con la colaboración de instituciones nacionales e internacionales, con el objetivo de estudiar la posible actividad antitumoral, antifúngica y antibacteriana de algunos de los nuevos compuestos sintetizados.spa
dc.description.abstractHeterocyclic compounds have an important place among the large groups or families of compounds that make up organic chemistry. This is not only due to its structural diversity and chemical properties, which makes them attractive as synthetic auxiliaries, but also because their heterocyclic nuclei are constituents of natural products and play a key role in biological processes. Their application as therapeutic agents for the treatment of various diseases also turns their structural units in targets of medicinal chemistry. This study is a summary of the research conducted by the author and his group on the subject of aminopyrazoles and their importance in the synthesis of heterocyclic compounds of greater complexity. The design, synthesis, and study of new compounds containing the pyrazole nucleus have been carried out in the Heterocyclic Compounds Research Group (GICH) of the Chemistry Department at Valle University where together with other national and international institutions, we have studied the possible antitumor, antifungal, and antibacterial activity of some of the new compounds.eng
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dc.publisherAcademia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 Internationalspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.sourceRevista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.titleLos 5-aminopirazoles como bloque de construcción de compuestos heterocíclicos fusionadosspa
dc.typeArtículo de revistaspa
dcterms.audienceEstudiantes, Profesores, Comunidad científica colombianaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.rights.creativecommonsAtribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)spa
dc.identifier.doihttps://doi.org/10.18257/raccefyn.762-
dc.subject.proposalHidracinasspa
dc.subject.proposalHydrazineseng
dc.subject.proposalNitrilosspa
dc.subject.proposalNitrileseng
dc.subject.proposalAminopirazolspa
dc.subject.proposalAminopyrazoleeng
dc.subject.proposalBielectrófilosspa
dc.subject.proposalBielectrophileseng
dc.subject.proposalCompuestos con metileno activospa
dc.subject.proposalMethylene active compoundseng
dc.subject.proposalPirazolopiridinaspa
dc.subject.proposalPyrazolopyridineeng
dc.subject.proposalPirazolopirimidinaspa
dc.subject.proposalPyrazolopyrimidineeng
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.relation.ispartofjournalRevista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.relation.citationvolume43spa
dc.relation.citationstartpage531spa
dc.relation.citationendpage538spa
dc.publisher.placeBogotá, Colombiaspa
dc.contributor.corporatenameAcademia Colombiana de Ciencias Exactas, Físicas y Naturalesspa
dc.relation.citationissue168spa
dc.type.contentDataPaperspa
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oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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