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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Sierra, Ligia | - |
| dc.date.accessioned | 2021-11-15T14:43:03Z | - |
| dc.date.available | 2021-11-15T14:43:03Z | - |
| dc.date.issued | 2016-12-26 | - |
| dc.identifier.uri | https://repositorio.accefyn.org.co/handle/001/956 | - |
| dc.description.abstract | Esta revisión comprende una descripción de los mecanismos propuestos para explicar el desarrollo de la enfermedad de Alzheimer (EA) y de las estrategias para su tratamiento a la luz de estos mecanismos, enfatizando la utilización de compuestos polifenólicos como agentes terapéuticos. Se analizan los efectos de especies reactivas de oxígeno ROS y presencia de metales redox en el desarrollo de EA y las estrategias de tratamiento, basadas en la actividad antioxidante y quelante de un medicamento y en sus alcances a través de vías de señalización. Dada la importancia de los polifenoles tipo flavonoides para el tratamiento de EA, se tienen en cuenta ejemplos con el flavonoide (-)-epigalocatequin-3-galato (EGCG), perteneciente a la familia de las catequinas. Es importante estudiar como intervienen los polifenoles a nivel celular (rol de su estructura química en la interacción con la célula y en su actividad biológica) con el fin de modular la interacción y las vías de señalización para lograr los efectos neurotróficos esperados. Los efectos in vitro, frecuentemente no corresponden a aquellos in vivo, dado que diferencias en concentraciones y condiciones de estudio hacen que las actividades química y biológica de un medicamento varíen. Esto puede ser debido en parte a la necesidad de un ajuste en concentraciones y tiempo entre los estudios pre clínicos y clínicos. Por otra parte, métodos de liberación eficientes deben ser investigados, teniendo en cuenta que un agente terapéutico para enfermedades neurológicas debería cruzar la barrera sanguínea-cerebral. La nanotecnología basada en sistemas de liberación controlada de medicamentos puede superar estas limitaciones. | spa |
| dc.description.abstract | This review includes a description of the proposed mechanisms to explain the development of Alzheimer’s disease (AD) and strategies for treatment in the light of these mechanisms, with emphasis on the use of polyphenolic compounds as therapeutic agents. The effects of reactive oxygen species ROS and presence of metal redox in the development of AD and treatment strategies with a drug or active substance, based on antioxidant and chelating activity and in its potentiality through signaling pathways are analyzed. Given the importance of polyphenolic compounds as natural antioxidants for treating of AD, in special the flavonoids family, this review takes into account examples of this family, with emphasis on the catechin type flavonoid (-)-epigalocatechin-3-gallate (EGCG). Understanding of how polyphenols are involved at the cellular level (role of its chemical structure in the interaction with the cell and therefore its biological activity is required in order to modulate the interaction and signaling pathways to achieve the desired neurotrophic effects. Effects in vitro often do not correspond to those in vivo. Differences in concentrations and study conditions make that chemical and biological activities of a drug vary. This may be due in part to the need for an adjustment in concentration and time between preclinical and clinical studies. Furthermore, efficient release methods should be investigated, particularly considering that a therapeutic agent for neurological diseases should cross the blood – brain - barrier (BBB). Nano- technology based on controlled release systems of drugs may overcome these limitations. | eng |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | spa | spa |
| dc.publisher | Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
| dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International | spa |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
| dc.source | Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
| dc.title | Estrategias de investigación para el tratamiento de Alzheimer con antioxidantes polifenólicos | spa |
| dc.type | Artículo de revista | spa |
| dcterms.audience | Estudiantes, Profesores, Comunidad científica colombiana | spa |
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| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.type.driver | info:eu-repo/semantics/article | spa |
| dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
| dc.rights.creativecommons | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | spa |
| dc.identifier.doi | https://doi.org/10.18257/raccefyn.408 | - |
| dc.subject.proposal | Enfermedad de Alzheimer | spa |
| dc.subject.proposal | Alzheimer’s disease | eng |
| dc.subject.proposal | Placas amiloide | spa |
| dc.subject.proposal | Amyloid-beta plaques | eng |
| dc.subject.proposal | Marañas tau | spa |
| dc.subject.proposal | Tau tangles | eng |
| dc.subject.proposal | Compuestos polifenólicos | spa |
| dc.subject.proposal | Polyphenolic compounds | eng |
| dc.subject.proposal | Vías de señalización | spa |
| dc.subject.proposal | Signaling pathways | eng |
| dc.subject.proposal | Liberación controlada de medicamentos | eng |
| dc.subject.proposal | Controlled drug release | eng |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
| dc.relation.ispartofjournal | Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
| dc.relation.citationvolume | 40 | spa |
| dc.relation.citationstartpage | 608 | spa |
| dc.relation.citationendpage | 620 | spa |
| dc.publisher.place | Bogotá, Colombia | spa |
| dc.contributor.corporatename | Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
| dc.relation.citationissue | 157 | spa |
| dc.type.content | DataPaper | spa |
| dc.type.redcol | http://purl.org/redcol/resource_type/ARTREV | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
| Appears in Collections: | BA. Revista de la Academia Colombiana de Ciencias Exactas Físicas y Naturales | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 9. Estrategias de investigación para el tratamiento de Alzheimer con antioxidantes polifenólicos.pdf | Ciencias Químicas | 393.77 kB | Adobe PDF |  View/Open |
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