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dc.contributor.author | Stühmer, Walter | - |
dc.date.accessioned | 2021-11-15T15:07:08Z | - |
dc.date.available | 2021-11-15T15:07:08Z | - |
dc.date.issued | 2017-10-09 | - |
dc.identifier.uri | https://repositorio.accefyn.org.co/handle/001/988 | - |
dc.description.abstract | Entre los más de 100 genes conocidos que codifican canales iónicos selectivos de potasio, el llamado Kv10.1 posee propiedades muy particulares que lo diferencian de los demás. El canal Kv10.1 es dependiente del voltaje y prácticamente se detecta únicamente en tejido nervioso. Sorprendentemente, se descubrió que se encuentra en más del 70 % de los cánceres humanos, y en tejidos de rápido crecimiento como la placenta, las células germinales del testículo o las criptas del colon. Su distribución subcelular ayudó a revelar su función en el ciclo celular, a lo largo del cual es regulado por factores de crecimiento y por los genes supresores de tumores p53 y RB1. El Kv10.1 también favorece la internalización del cilio primario, paso indispensable para la división celular. Dado que las células cancerosas se dividen rápidamente o presentan alteraciones en la función de los factores de crecimiento o en los mencionados genes, suelen expresar el Kv10.1, lo cual se puede detectar usando anticuerpos que actúan contra él. Los pacientes en cuyos tumores se detectan altos niveles de Kv10.1 tienen un peor pronóstico que aquellos con niveles bajos. Además, el bloqueo de la función del Kv10.1 permite reducir la proliferación celular, lo cual lo convierte en un nuevo marcador diagnóstico del cáncer, y en un blanco para su tratamiento. | spa |
dc.description.abstract | Among the over 100 genes that encode for the various potassium channels known so far, the Kv10.1 exhibits properties that are quite unique. It is voltage-dependent and expressed almost exclusively in the nervous system. Surprisingly, it was found overexpressed in more than 70% of human cancer tissue of diverse origin, as well as in fast growing tissue such as placenta, germinal cells of testicles and in colon crypts. Its sub-cellular distribution allowed for elucidating its role in the cell cycle, during which it is regulated by growth factors and tumor suppressor genes such as the p53 and the RB1. In addition, Kv10.1 favors the internalization of the primary cilium, which is essential for cell division. Given that tumor cells grow and divide rapidly because they often have defective growth-factor signaling or defects in one of the mentioned genes, they frequently over-express Kv10.1, which can be detected using specific antibodies. Patients with high levels of Kv10.1 in their tumors have worse prognosis than those with low levels. In addition, blocking the function of Kv10.1 allows reducing cell proliferation. Therefore, Kv10.1 offers a novel diagnostic and therapeutic window in cancer treatment. | eng |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | spa | spa |
dc.publisher | Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
dc.rights | Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International | spa |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | spa |
dc.source | Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
dc.title | El canal de potasio dependiente de voltaje Kv10.1 y el cáncer | spa |
dc.type | Artículo de revista | spa |
dcterms.audience | Estudiantes, Profesores, Comunidad científica colombiana | spa |
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dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
dc.type.driver | info:eu-repo/semantics/article | spa |
dc.type.version | info:eu-repo/semantics/publishedVersion | spa |
dc.rights.creativecommons | Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0) | spa |
dc.identifier.doi | https://doi.org/10.18257/raccefyn.509 | - |
dc.subject.proposal | Canales iónicos | spa |
dc.subject.proposal | Ion channels | eng |
dc.subject.proposal | Cambio conformacional dependiente de voltaje | spa |
dc.subject.proposal | Voltage-gating | eng |
dc.subject.proposal | División celular | spa |
dc.subject.proposal | Cell division | eng |
dc.subject.proposal | Cáncer | spa |
dc.subject.proposal | Cancer | eng |
dc.subject.proposal | Cilio primario | spa |
dc.subject.proposal | Primary cilium | eng |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
dc.relation.ispartofjournal | Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
dc.relation.citationvolume | 41 | spa |
dc.relation.citationstartpage | 274 | spa |
dc.relation.citationendpage | 280 | spa |
dc.publisher.place | Bogotá, Colombia | spa |
dc.contributor.corporatename | Academia Colombiana de Ciencias Exactas, Físicas y Naturales | spa |
dc.relation.citationissue | 160 | spa |
dc.type.content | DataPaper | spa |
dc.type.redcol | http://purl.org/redcol/resource_type/ART | spa |
oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
Appears in Collections: | BA. Revista de la Academia Colombiana de Ciencias Exactas Físicas y Naturales |
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