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Title: Experimental pulmonary fibrosis induced by paracoccidioides brasiliensis conidia: measurement of local host responses
Authors: Franco, L.
Najvar, L.
Gómez, B. L.
Restrepo, S.
Graybill, J. R.
Restrepo Moreno, Ángela
journal@ajtmh.org
Issue Date: 1998
Publisher: American Society of Tropical Medicine and Hygiene USA
Abstract: Se indujo fibrosis pulmonar tras la inoculación de conidios de Paracoccidioides brasiliensis por vía intranasal en ratones BALB / c. La fibrosis se asoció con la formación de granulomas, aumento de la hidroxiprolina pulmonar y aumentos sostenidos del factor de necrosis tumoral tisular alfa y del factor de crecimiento transformante beta. Este estudio sugiere un papel de estas citocinas en la generación de fibrosis pulmonar asociada con enfermedades infecciosas granulomatosas crónicas.
Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-alpha and transforming growth factor-beta. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.
URI: https://repositorio.accefyn.org.co/handle/001/1054
ISSN: 00029637
Document url: https://doi.org/10.4269/ajtmh.1998.58.424
DOI: 10.4269/ajtmh.1998.58.424
Appears in Collections:DHAE Paracoccidioidomicosis. Inmunología

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